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Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. Examples of such treatments include the following:
Prednisone and azathioprine – For autoimmune hepatitis
Interferon and other antiviral agents – For hepatitis B and C
Phlebotomy – For hemochromatosis
Ursodeoxycholic acid – For primary biliary cirrhosis
Trientine and zinc – For Wilson disease
Once cirrhosis develops, treatment is aimed at the management of complications as they arise. Examples include the following:
Hepatorenal syndrome – Kidney function usually recovers when patients with cirrhosis and hepatorenal syndrome undergo liver transplantation; patients with early hepatorenal syndrome may be salvaged by aggressive expansion of intravascular volume with albumin and fresh frozen plasma and by avoidance of diuretics
Hepatic encephalopathy – Pharmacologic treatment includes the administration of lactulose and antibiotics
Ascites – Treatment can include sodium restriction and the use of diuretics, large-volume paracentesis, and shunts (peritoneovenous, portosystemic, transjugular intrahepatic portosystemic)
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